Rejuran Polynucleotide Biostimulation

Rejuran polynucleotide treatment at L centrum Pardubice uses salmon-derived PDRN (polydeoxyribonucleotide) — a biological extract that stimulates the skin's own repair and regeneration pathways from within. When injected into the dermis, the polynucleotide fragments act as biological growth factor stimulants, activating fibroblasts to produce new collagen, improving skin elasticity and reducing the appearance of fine lines and pores. Unlike fillers that add volume mechanically, Rejuran works by triggering the skin's biological repair response, resulting in healthier, thicker skin over a course of treatment. The product is widely used in South Korea and gaining clinical adoption across Europe for its documented skin quality improvement effect.

Rejuran (PDRN — polydeoxyribonucleotide) biostimulation at L centrum Pardubice represents the clinic's offering in the category of injectable biological tissue repair agents, distinct from hyaluronic acid fillers (which add volume) and botulinum toxin (which reduces muscle activity). PDRN is a purified extract of salmon sperm DNA that has undergone extensive fragmentation and sterilisation; the resulting polynucleotide chains are structurally compatible with human adenosine receptors in skin fibroblasts, where they act as agonists at the A2A receptor — a receptor subtype linked to cell survival, proliferation and the downregulation of inflammatory cytokines. The net biological effect in the dermis is a shift toward tissue anabolism: fibroblast activity increases, collagen and elastin synthesis is upregulated, microcirculation improves via angiogenic factor release, and the inflammatory microenvironment is modulated away from chronically elevated pro-inflammatory signalling. The practical outcome reported by patients is improved skin texture, reduced pore visibility, enhanced elasticity, and a gradual reduction in fine wrinkles and skin dullness associated with photoageing and intrinsic skin ageing. Unlike fillers, the improvement from Rejuran is biological rather than mechanical — the skin becomes intrinsically thicker and more resilient rather than being temporarily filled from outside. A typical course involves multiple sessions spaced 2–4 weeks apart, with the degree of improvement progressively compounding as collagen deposition accumulates. Maintenance sessions are scheduled every 6–12 months to sustain the achieved quality level. The Rejuran product used at L centrum Pardubice is the standard formulation for skin biostimulation; the physician selects injection depth and distribution based on the specific concerns addressed — superficial mesotherapy-depth injections for fine-line and texture work, slightly deeper placement for structural skin quality improvement. The treatment is notably well tolerated: PDRN's biocompatibility with human tissue reduces the risk of hypersensitivity reactions, and the injection discomfort is comparable to other superficial dermal injections of similar needle gauge.