Type
General Skin Treatment
Duration
45 min
What's included
4 deliverables in this treatment
- Aesthetic medicine consultation and suitability assessment
- Polynucleotide injection session in the agreed area
- Topical anaesthetic if required
- Aftercare guidance and series scheduling (typically 2–3 sessions)
Klinika Esthé offers polynucleotide injections — a newer class of regenerative injectable derived from purified DNA fragments — to improve skin quality, elasticity and hydration in areas where fillers are unsuitable, such as the under-eye region, neck and lower face. Polynucleotides are associated with fibroblast stimulation and tissue-repair support rather than volume addition, making them a natural-looking option for skin that looks tired, thin or crepey. Sessions take under an hour with minimal downtime and are performed by the clinic's aesthetic medicine physicians.
About this treatment
Polynucleotides (PN/PDRN) are purified, fragmented DNA chains of biological origin that, when injected into the skin, are associated with fibroblast activation, improved tissue hydration and a better environment for dermal repair. Unlike cross-linked hyaluronic acid fillers, they add essentially no volume — their role is regenerative: improving skin thickness, elasticity, tone and the appearance of fine crepey texture. This makes them particularly useful…
The session at Esthé
after physician assessment, the product is placed via a series of small injections or micro-boluses into the target zone. Topical anaesthetic can be used. The session takes 30–45 minutes; small injection-point bumps and possible light bruising settle over 24–72 hours.
Good to know
- Mechanism
- Regenerative (fibroblast support) — not a volumising filler
- Best areas
- Under-eye, neck, lower face, crepey skin
- Course
- 2–3 sessions, 3–4 weeks apart
- Downtime
- 24–72 hours of small bumps / possible light bruising
Who is this for?
Tired-looking under-eye skin, thin or crepey skin, neck skin quality, patients unsuited to fillers
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
184 clinic reviews
From independent platforms
Clinical team
The clinic is led by doc. MUDr. Ondřej Měšťák, Ph.D. (head plastic surgeon, clinic director since 2023) alongside founder doc. MUDr. Jan Měšťák, CSc. (emeritus head). The surgical team includes MUDr. Petr Polák (deputy head), MUDr. Marek Kubík, MUDr. Veronika Hromádková and MUDr. Iveta Borges (plastic surgeons), supported by MUDr. Radim Kaňa, Ph.D. (ENT for septoplasty), MUDr. Pavel Vokálek (anaesthesiology), MUDr.…
Languages: Czech, English, German, Polish
Treatment highlights
- Aesthetic medicine consultation and suitability assessment
- Polynucleotide injection session in the agreed area
+2 more items in What's included
From 6,500 Kč per session depending on product and treated area. Polynucleotide protocols are usually delivered as a series of 2–3 sessions spaced 3–4 weeks apart.