IV NAD+

An intravenous infusion of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in every living cell that is essential for energy metabolism, DNA repair, and cellular signalling. NAD+ levels decline naturally with age, and supplementation through IV delivery is being explored for its potential to support cellular energy, cognitive function, and healthy ageing.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in all living cells that plays a fundamental role in hundreds of metabolic processes. It is essential for the conversion of nutrients into cellular energy (ATP) through its role in glycolysis, the Krebs cycle, and oxidative phosphorylation. NAD+ also activates sirtuins — a family of proteins associated with DNA repair, gene expression regulation, and cellular stress resistance — and serves as a substrate for PARP enzymes involved in DNA damage repair. NAD+ levels decline with age, and this decline is associated with reduced mitochondrial function, increased oxidative stress, and impaired cellular repair mechanisms. Research into NAD+ supplementation is ongoing, with studies exploring its potential effects on cognitive function, physical endurance, metabolic health, and biological ageing markers. IV delivery of NAD+ bypasses the digestive system entirely, delivering the molecule directly into the bloodstream. Oral NAD+ precursors (like NMN or NR) must be converted through multiple enzymatic steps, and their efficiency varies. IV NAD+ provides the active form immediately. NAD+ infusions are typically slower than standard IV drips — sessions run approximately 90 to 120 minutes or longer depending on the dose. The infusion rate is carefully controlled because rapid delivery can cause temporary flushing, chest tightness, or nausea. A registered nurse monitors the entire session and adjusts the drip rate for comfort.