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SIBO Check - Glucose + Lactulose

Type

Blood Testing

Biomarkers

8

Duration

30 min

Results

24 hours

Comprehensive breath test to detect small intestinal bacterial overgrowth (SIBO).

Diabetes and metabolic screening tests measure how well your body processes glucose — your primary fuel source. Fasting glucose gives a snapshot of your blood sugar after an overnight fast, while HbA1c reveals your average blood sugar over the past 2–3 months by measuring the percentage of hemoglobin proteins coated with sugar. An insulin test can detect insulin resistance — where your cells stop responding efficiently to insulin — often years before blood sugar levels rise into the diabetic range. This early detection window is critical because prediabetes and insulin resistance are reversible with lifestyle changes, while advanced type 2 diabetes requires lifelong management.

Key Details

Biomarkers
2–4 metabolic markers
Fasting Required
Yes, 10–12 hours for fasting glucose
Sample Type
Blood draw
Turnaround
Same day to 24 hours
Common Use
Diabetes screening, insulin resistance detection

Who Is This For?

Adults over 35 as part of routine screening (diabetes affects 1 in 10 adults globally). Anyone with a family history of type 2 diabetes. People who are overweight or physically inactive. Those experiencing increased thirst, frequent urination, unexplained weight loss, or fatigue. Women with a history of gestational diabetes or polycystic ovary syndrome (PCOS).

What's Included

Fasting blood glucose
HbA1c (glycated hemoglobin)
Fasting insulin (if included in panel)
HOMA-IR insulin resistance index (if insulin included)

Preparation Required

Fasting for 10–12 hours before your appointment is recommended for accurate results (water is fine). Avoid alcohol for 24 hours and intense exercise for 12 hours before the blood draw. Morning appointments are ideal for consistent hormone and glucose readings. The blood draw typically takes 5–10 minutes.

Biomarkers Tested

8
Hydrogen increase over baseline by 90 mins ppm

Bacteria in the small intestine produce hydrogen and methane when exposed to glucose. SIBO may be diagnosed with a rise in breath hydrogen of >20ppm in the first 90 minutes.

Peak methane excretion over baseline ppm

Bacteria in the small intestine produce hydrogen and methane gas when exposed to glucose. SIBO may be diagnosed with a rise in breath methane of >10ppm above the baseline.

Hydrogen increase over baseline by 90 mins ppm

Bacteria in the small intestine produce hydrogen and methane when exposed to glucose. SIBO may be diagnosed with a rise in breath hydrogen of >20ppm in the first 90 minutes.

Peak methane level at any point ppm

Bacteria in the small intestine produce hydrogen and methane gas when exposed to lactulose. Methane excretion is indicated by >10ppm sustained rise upon lactulose challenge.

OCTT (oro-caecal transit time) minutes

Normal OCTT (the time it takes for lactulose to pass through the gut) in healthy adults is approx 60-120min.

Glucose mg/dL

Blood sugar — the body's primary energy source. Fasting glucose screens for diabetes and prediabetes. Chronically elevated glucose damages blood vessels and organs. Levels fluctuate with meals, stress, and physical activity.

HbA1c (Glycated Haemoglobin) %

Reflects your average blood sugar over the past 2–3 months by measuring the percentage of hemoglobin with attached glucose. HbA1c is the gold standard for diagnosing and monitoring diabetes, unaffected by daily fluctuations.

Insulin µIU/mL

The hormone produced by the pancreas to regulate blood sugar. Elevated fasting insulin — even with normal glucose — is an early marker of insulin resistance, which precedes type 2 diabetes by years. Key biomarker in longevity medicine.

Frequently Asked Questions