Longevity.haus
i-Screen i-Screen

SAM and SAH Check

Type

Blood Testing

Biomarkers

3

Duration

30 min

Results

7 days

Blood test measuring S-Adenosylmethionine (SAMe), S-Adenosylhomocysteine (SAH), and their ratio to assess methylation status.

Specialty biomarker testing measures advanced markers that go beyond standard blood panels to provide deeper insight into specific biological pathways. These tests are commonly used in functional and integrative medicine to identify root causes of symptoms, assess cellular health, and guide personalized treatment protocols. Markers like IGF-1 reflect growth hormone activity and aging, lipoprotein(a) reveals inherited cardiovascular risk invisible to standard lipid panels, and neurotransmitter profiles can explain mood and cognitive symptoms. Results enable highly targeted interventions that standard tests would miss.

Key Details

Sample
Test-specific (blood, urine, or saliva)
Results
3–10 business days

Who Is This For?

People working with functional or integrative medicine practitioners. Those seeking root-cause analysis beyond standard blood work. Longevity enthusiasts tracking advanced biomarkers. Anyone with persistent symptoms despite normal standard labs.

What's Included

Advanced biomarker analysis
Results with functional medicine reference ranges
Clinical interpretation and recommendations

Preparation Required

Fasting may be required depending on the specific marker. Follow your clinic's instructions. Some tests require morning samples for accurate results. Bring a list of all supplements — many affect these markers.

Biomarkers Tested

3
S-Adenosylmethionine (SAMe) µmol/L

A universal methyl donor involved in methylation reactions crucial for DNA synthesis, mental health, and detoxification.

S-Adenosylhomocysteine (SAH) µmol/L

Precursor to homocysteine and byproduct of SAMe-dependent methylation; elevated levels indicate impaired methylation.

SAM/SAH Ratio ratio

Reflects the balance between methylation reactions; provides insights into cellular health, metabolism, and disease.

Frequently Asked Questions