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Liver Function Check

Type

Blood Testing

Biomarkers

17

Duration

30 min

Results

24 hours

Liver function test examining enzymes and markers for liver damage.

A liver function panel measures enzymes and proteins produced by or processed through the liver — the body's largest internal organ and a critical hub for detoxification, protein synthesis, and bile production. The panel typically includes ALT and AST (enzymes released when liver cells are damaged), ALP and GGT (markers of bile duct function), bilirubin (a waste product processed by the liver), and albumin (a protein the liver produces). Elevated levels can indicate liver inflammation, fatty liver disease, hepatitis, alcohol-related damage, or bile duct obstruction. With non-alcoholic fatty liver disease affecting roughly 25% of adults globally, regular liver screening has become increasingly important.

Key Details

Biomarkers
6–8 liver markers
Fasting Required
Not strictly required, but recommended
Sample Type
Blood draw
Turnaround
Same day to 24 hours
Common Use
Liver health, medication monitoring

Who Is This For?

Anyone who consumes alcohol regularly and wants to monitor liver health. People taking medications that can affect the liver (statins, acetaminophen, certain antibiotics). Those with risk factors for fatty liver disease including obesity, type 2 diabetes, or metabolic syndrome. Individuals with a family history of liver disease or hepatitis.

What's Included

Alanine aminotransferase (ALT)
Aspartate aminotransferase (AST)
Alkaline phosphatase (ALP)
Gamma-glutamyl transferase (GGT)
Total and direct bilirubin
Albumin and total protein

Preparation Required

Fasting for 10–12 hours before your appointment is recommended for accurate results (water is fine). Avoid alcohol for 24 hours and intense exercise for 12 hours before the blood draw. Morning appointments are ideal for consistent hormone and glucose readings. The blood draw typically takes 5–10 minutes.

Biomarkers Tested

17
Bilirubin mg/dL

Bilirubin is a substance produced during the normal breakdown of red blood cells. High levels can lead to jaundice and indicate liver or bile duct problems.

Direct Bilirubin µmol/L

Elevated levels may indicate a liver or bile duct blockage.

Alkaline Phosphatase (ALP) U/L

An enzyme found in the liver, bones, kidneys, and digestive system. Elevated ALP can indicate bile duct obstruction, liver disease, or bone disorders. It's normally higher in children and during pregnancy due to bone growth.

Aspartate Aminotransferase (AST) U/L

Enzyme from liver and heart; high levels indicate liver damage.

Albumin g/dL

The most abundant protein in blood, produced by the liver. Albumin maintains blood volume and pressure, and transports hormones, vitamins, and drugs. Low levels indicate liver disease, kidney disease, malnutrition, or chronic inflammation.

Globulin g/dL

A group of proteins in blood including antibodies (immunoglobulins), transport proteins, and enzymes. Elevated globulin can indicate chronic infection, inflammation, or blood cancers. Calculated by subtracting albumin from total protein.

Total Protein g/dL

Measures the combined amount of albumin and globulin proteins in your blood. These proteins are essential for fighting infections, blood clotting, and transporting substances throughout the body.

Sodium mEq/L

The primary electrolyte regulating fluid balance and blood pressure. Sodium is essential for nerve impulses and muscle contractions. Abnormal levels can cause confusion, seizures, and cardiac arrhythmias.

Potassium mEq/L

A critical electrolyte for heart rhythm, muscle contractions, and nerve function. Both high and low potassium can cause dangerous cardiac arrhythmias. Levels are influenced by kidney function, medications, and diet.

Chloride mEq/L

An electrolyte that works with sodium to maintain fluid balance, blood pressure, and acid-base balance. Chloride abnormalities often accompany sodium abnormalities and can indicate dehydration, kidney disease, or metabolic disorders.

Bicarbonate mEq/L

A key component of the body's acid-base buffering system. Bicarbonate levels reflect the balance between acids and bases in the blood. Abnormal values help diagnose metabolic acidosis or alkalosis.

Urea mg/dL

A waste product from protein breakdown, processed by the liver and excreted by the kidneys. Elevated urea levels can indicate kidney dysfunction, dehydration, high-protein diet, or gastrointestinal bleeding.

Creatinine mg/dL

A waste product from normal muscle metabolism, filtered by the kidneys. Blood creatinine levels reflect kidney filtration capacity. Elevated levels may indicate impaired kidney function, dehydration, or excessive muscle breakdown.

Estimated Glomerular Filtration Rate (eGFR) mL/min/1.73m²

An estimated measure of how well your kidneys filter waste from the blood. It's calculated from creatinine levels, age, sex, and race. eGFR is the primary marker used to stage chronic kidney disease.

ALT (Alanine Aminotransferase) U/L

A liver enzyme that helps convert proteins into energy. ALT is found primarily in the liver, making it a highly specific marker for liver damage. Elevated levels may indicate hepatitis, fatty liver disease, or medication-related liver injury.

AST (Aspartate Aminotransferase) U/L

An enzyme found in the liver, heart, and muscles. While less liver-specific than ALT, elevated AST can indicate liver damage, heart attack, or muscle injury. The AST/ALT ratio helps distinguish between different liver conditions.

GGT (Gamma-Glutamyl Transferase) U/L

A liver enzyme sensitive to alcohol use and bile duct problems. GGT is often the first liver enzyme to rise when bile ducts are blocked. Combined with ALP, it helps determine whether elevated ALP is from liver or bone.

Frequently Asked Questions