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Cystatin C

Type

Blood Testing

Biomarkers

7

Duration

30 min

Results

24 hours

Blood test to screen for and monitor kidney dysfunction.

A kidney function panel evaluates how effectively your kidneys are filtering waste from your blood. The kidneys process around 200 liters of blood daily, removing toxins, balancing electrolytes, and regulating blood pressure. Key markers include creatinine (a waste product from muscle metabolism filtered by the kidneys), BUN/urea (a breakdown product of protein), and eGFR (estimated glomerular filtration rate — the gold standard for measuring kidney function). Some panels also include cystatin C, which provides a more accurate filtration estimate independent of muscle mass. Chronic kidney disease affects roughly 10% of adults worldwide and is often called a "silent" disease because it typically causes no symptoms until advanced stages.

Key Details

Biomarkers
4–7 kidney markers
Fasting Required
Recommended for accurate results
Sample Type
Blood draw
Turnaround
Same day to 24 hours
Common Use
Kidney function screening, medication monitoring

Who Is This For?

People with diabetes or high blood pressure — the two leading causes of kidney disease. Anyone taking medications that can affect kidney function (NSAIDs, certain antibiotics, ACE inhibitors). Those over 60, as kidney function naturally declines with age. Individuals with a family history of kidney disease or who have had recurrent urinary tract infections.

What's Included

Creatinine
Blood urea nitrogen (BUN) / Urea
Estimated glomerular filtration rate (eGFR)
Electrolytes (sodium, potassium, chloride)

Preparation Required

Fasting for 10–12 hours before your appointment is recommended for accurate results (water is fine). Avoid alcohol for 24 hours and intense exercise for 12 hours before the blood draw. Morning appointments are ideal for consistent hormone and glucose readings. The blood draw typically takes 5–10 minutes.

Biomarkers Tested

7
Cystatin C mg/L

A protein produced by all nucleated cells at a constant rate, filtered by the kidneys. Cystatin C is a more accurate marker of kidney function than creatinine because it's less affected by muscle mass, age, and diet.

Creatinine mg/dL

A waste product from normal muscle metabolism, filtered by the kidneys. Blood creatinine levels reflect kidney filtration capacity. Elevated levels may indicate impaired kidney function, dehydration, or excessive muscle breakdown.

Urea mg/dL

A waste product from protein breakdown, processed by the liver and excreted by the kidneys. Elevated urea levels can indicate kidney dysfunction, dehydration, high-protein diet, or gastrointestinal bleeding.

Estimated Glomerular Filtration Rate (eGFR) mL/min/1.73m²

An estimated measure of how well your kidneys filter waste from the blood. It's calculated from creatinine levels, age, sex, and race. eGFR is the primary marker used to stage chronic kidney disease.

Sodium mEq/L

The primary electrolyte regulating fluid balance and blood pressure. Sodium is essential for nerve impulses and muscle contractions. Abnormal levels can cause confusion, seizures, and cardiac arrhythmias.

Potassium mEq/L

A critical electrolyte for heart rhythm, muscle contractions, and nerve function. Both high and low potassium can cause dangerous cardiac arrhythmias. Levels are influenced by kidney function, medications, and diet.

Chloride mEq/L

An electrolyte that works with sodium to maintain fluid balance, blood pressure, and acid-base balance. Chloride abnormalities often accompany sodium abnormalities and can indicate dehydration, kidney disease, or metabolic disorders.

Frequently Asked Questions