GrimAge Biological Age Test

Exclusive access to GrimAge in Australia - the gold standard biological age test developed by UCLA Horvath Lab. Analyzes DNA methylation markers across 8 protein markers (PAI-1, Cystatin C, Leptin, TIMP1, ADM, B2M, GDF15) plus smoking history. Measures cellular aging to predict age-related disease and mortality risk. Non-invasive sample collection with detailed results review.

The GrimAge biological age test measures how your body is ageing at the cellular level using epigenetic DNA methylation analysis — the most scientifically validated method for determining biological (as opposed to chronological) age. HealthScreen offers what they describe as exclusive Australian access to this technology. GrimAge analyses eight DNA methylation-based surrogate protein markers: PAI-1 (plasminogen activation inhibitor 1, linked to cardiovascular risk and clotting), Cystatin C (kidney function and cardiovascular mortality), Leptin (metabolic regulation and obesity), TIMP1 (tissue remodelling and fibrosis), Adrenomedullin (vascular function), Beta-2-microglobulin (immune function and inflammation), GDF15 (cellular stress and ageing), and self-reported smoking pack-years. The test predicts age-related disease risk, tracks the effectiveness of anti-ageing interventions over time, monitors the rate of biological ageing, and evaluates immune system ageing (immunosenescence). It is particularly valuable for anyone implementing longevity interventions — diet, exercise, supplementation, pharmaceuticals — who wants objective measurement of whether those interventions are actually slowing biological ageing. The process involves a non-invasive blood sample collected at the Melbourne or Sydney clinic, followed by laboratory DNA methylation analysis and a detailed results consultation with personalised longevity recommendations.