Type
Blood Testing
Duration
2 hours
Sample
Blood (venous draw) + ultrasound
What's included
4 deliverables in this treatment
- All elements of basic first-trimester combined screening (PAPP-A, free β-hCG, NT ultrasound)
- PlGF (placental growth factor) serum measurement
- Uterine artery Doppler pulsatility index measurement
- Blood pressure measurement at 11–14 weeks
The extended first-trimester combined screening at G-CENTRUM Olomouc builds on the basic chromosomal risk assessment by adding preeclampsia screening — a critical distinction for women at higher risk of developing this serious blood pressure complication later in pregnancy. In addition to the PAPP-A and free β-hCG blood markers and the nuchal translucency ultrasound, the extended version includes measurement of PlGF (placental growth factor) in the blood, uterine artery Doppler flow measurement by ultrasound, and blood pressure assessment. These additional data points allow calculation of a personalised preeclampsia risk score alongside the chromosomal risk figures.
About this treatment
Preeclampsia affects 2–5% of pregnancies and is a leading cause of maternal and perinatal morbidity worldwide. First-trimester preeclampsia screening — when integrated with the standard chromosomal screening — allows identification of high-risk women at 11–14 weeks, when prophylactic low-dose aspirin is most effective at reducing risk of preterm preeclampsia (the more severe early-onset form).
G-CENTRUM Olomouc's extended first-trimester screening follows the Fetal Medicine Foundation (FMF) protocol, which combines four elements into a single algorithmic risk score:
- 1 Maternal biophysical factors and history (age, weight, ethnicity, obstetric history, blood pressure at 11–14 weeks)
- 2 Biochemical marker — PlGF (placental growth factor): low levels of this placenta-derived protein at 11–14 weeks are strongly predictive of placental insufficiency and preterm preeclampsia
- 3 Uterine artery Doppler: the pulsatility index of the uterine arteries is measured by ultrasound; elevated resistance indicates impaired placentation
- 4 All standard chromosomal screening elements (PAPP-A, free β-hCG, nuchal translucency)
Good to know
- Additional over basic
- PlGF + uterine Doppler + BP measurement
- Preterm preeclampsia detection
- ~75–95% at 10% screen-positive rate
- Protocol
- Fetal Medicine Foundation (FMF) algorithm
- Cost over basic
- +200 Kč (1,900 Kč vs 1,700 Kč)
Who is this for?
Pregnant women with risk factors for preeclampsia (first pregnancy, prior preeclampsia, multiple pregnancy, hypertension, diabetes, BMI >35) or any woman wanting comprehensive first-trimester risk profiling
Preparation required
Same two-step schedule as basic screening: blood draw at 9–10 weeks, ultrasound + blood pressure at 11–14 weeks. No fasting required.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
G-CENTRUM Olomouc is led by founder MUDr. Aleš Skřivánek, Ph.D., a gynecologist with over 35 years of clinical experience practicing since 1989. The team includes MUDr. Iveta Humlová, MUDr. Eva Hajkrová, MUDr. Jana Jelínková, and MUDr. Tomáš Kilián for outpatient gynecology and prenatal care. Urogynecology is covered by MUDr. Radovan Vrtal, Ph.D. and MUDr. Lukáš Kučera. Infertility diagnosis is managed by MUDr. Jan…
Languages: cs, en
What clients say
"{"author":"Andrea Musálková","text":"Pan doktor je velmi profesionální, vše dokáže dokonale vysvětlit i poradit. Má super lidský přístup.","platform":"ZnámýLékař.cz","translated":"The doctor is very professional, can explain everything perfectly and give advice. He has a great human approach."}"
"{"author":"NŠ","text":"Nejlepší gynekolog široko daleko. Pan doktor opravdu ví, co dělá.","platform":"ZnámýLékař.cz","translated":"The best gynecologist far and wide. The doctor really knows what he is doing."}"
Treatment highlights
- All elements of basic first-trimester combined screening (PAPP-A, free β-hCG, NT ultrasound)
- PlGF (placental growth factor) serum measurement
+2 more items in What's included
1,900 Kč total for the extended combined screening — includes everything in the basic screening plus PlGF serum marker for preeclampsia risk, uterine artery Doppler ultrasound, and blood pressure measurement.