Mesotherapy — Skin Rejuvenation

Mesotherapy at Esthetic Medical involves the microinjection of a customised cocktail of vitamins, hyaluronic acid, amino acids, and peptides directly into the dermis or subcutaneous layer, delivering active ingredients precisely where they are needed for maximum effect. The clinic is certified for mesotherapy and offers it for facial skin rejuvenation (hydration, fine line reduction, radiance), hair loss (stimulating follicle activity), and body treatments (cellulite, localised fat). Sessions take approximately 45 minutes and require no general anaesthesia — a topical cream is applied before the microinjections.

Mesotherapy was formalised in France in the 1950s by Dr. Michel Pistor, based on the principle of administering small quantities of therapeutic agents directly into the mesoderm (middle skin layer) rather than relying on systemic delivery or topical absorption across the skin's barrier. At Esthetic Medical — which holds formal certification in the technique — mesotherapy cocktails are formulated to the indication and injected via very fine needles into the papillary or reticular dermis, or subcutaneously depending on the target tissue. For facial skin rejuvenation, the standard cocktail typically contains hyaluronic acid (non-cross-linked, used for its hydrating and fibroblast-stimulating properties), a vitamin complex (C, B5, B6, B12, biotin, and folic acid for antioxidant and cofactor support), amino acids (glycine, proline, lysine — the building blocks of collagen), and growth peptides such as matrixyl or argireline. These ingredients are delivered to the papillary dermis where they are unavailable to topical skincare (skin barrier limits penetration to less than 3% of most actives). The immediate response is microinflammation that resolves within 24 hours; the sustained response is upregulated fibroblast activity, improved hydration, and visible plumping of fine lines over 4–6 weeks. A course of 4–6 sessions monthly is the standard protocol. For hair loss, mesotherapy delivers a cocktail of minoxidil, dutasteride, biotin, vitamins, and growth factors directly to the perifollicular tissue in the scalp dermis, bypassing the systemic absorption limitations of topical minoxidil and the side-effect profile of oral antiandrogens. The clinic prices hair mesotherapy from 1,800 Kč per session — accessible for a series approach. Treatment frequency is typically every 2–4 weeks for the first four sessions, then monthly. For body indications (cellulite, localised fat, stretch marks), lipolytic agents such as phosphatidylcholine, L-carnitine, artichoke extract, and caffeine are incorporated into the cocktail alongside hyaluronic acid. The injections are placed superficially in the subcutaneous zone across the target area. The clinic combines body mesotherapy with its device-based body-contouring menu for a comprehensive programme.