Injection Lipolysis — Fat Dissolving

Injection lipolysis at Esthetic Medical uses phosphatidylcholine-based solutions injected directly into small, localised fat deposits to dissolve the fat cell membrane and trigger natural clearance via the lymphatic system. The primary indication at this clinic is the double chin (submental fat), though the technique is also applied to small fatty deposits elsewhere on the body and face. From 1,500 Kč per session, it offers a cost-effective, needle-only alternative to surgery for stubborn fat pockets that do not respond to diet and exercise. Results develop gradually over 4–8 weeks post-treatment.

Injection lipolysis (also known as mesotherapy for fat) involves the intradermal or subcutaneous injection of a lipolytic agent — most commonly phosphatidylcholine (PC) and deoxycholate (DC) — directly into the adipose tissue. PC is a phospholipid that disrupts the adipocyte cell membrane's structural integrity, while DC acts as a detergent-like emulsifier. Together they cause fat cell lysis, releasing their lipid contents as free fatty acids and glycerol, which are then taken up by the bloodstream and metabolised or cleared by macrophages through the lymphatic system. At Esthetic Medical, the most common indication for injection lipolysis is submental fat reduction — the 'double chin' that remains despite overall weight control. A grid of fine-needle injections is placed across the submental and submandibular fat pad using very short needles. The session takes 20–30 minutes including the brief topical anaesthetic application. Patients experience swelling and firmness at the injection sites for 3–7 days as the inflammatory cascade processes the lysed fat — this is a normal and expected part of the mechanism, not a side effect. Full results become apparent 4–8 weeks after each session as the lymphatic system clears the metabolic products. Most patients require 2–4 sessions spaced 6–8 weeks apart to achieve their desired degree of contour improvement in the submental area. For smaller body zones (inner knees, localised abdominal fat pockets), fewer sessions may suffice. Injection lipolysis is not a weight-loss treatment — it is most effective for patients within their target weight range who have a specific resistant fat deposit. At Esthetic Medical the technique complements the device-based body-contouring menu (cryolipolysis, Vanquish, Exilis) and may be combined with them for a comprehensive programme. Pricing starts at 1,500 Kč per session, making it one of the more accessible body-contouring options at the clinic.