Botulinum Toxin — Anti-Wrinkle Injections

Botulinum toxin works by blocking the neuromuscular junction: a precisely measured dose inhibits the release of acetylcholine at the nerve terminal, preventing the targeted muscle from contracting. When the muscle beneath a wrinkle is relaxed, the overlying skin stops being folded thousands of times a day with each facial expression — and the crease gradually softens. The effect is dose-dependent and reversible: as the nerve terminal regenerates its…

At Estetické centrum Praha the procedure begins with MUDr. Renata Handlová mapping the patient's facial dynamics — how the brow engages, where the frown forms, the extent and character of periocular wrinkling at different expressions. This movement analysis, combined with her years of ophthalmic anatomy training, guides exactly where and how deeply each injection is placed. The frontalis muscle produces horizontal forehead lines; the corrugators and…

Using ultra-fine needles, the injections themselves are completed in under fifteen minutes. Patients are advised to remain upright for four to five hours post-treatment, to avoid strenuous physical activity and saunas for two days, and to refrain from facial massage or pressure to the injected areas for one week — all measures to prevent unintended product migration. The onset of effect is visible within two to three days, reaching its full expression at…