Polynucleotides (Rejuran) — DNA Biorevitalisation

Polynucleotides — sold under brand names including Rejuran — are purified DNA fragments derived from salmon sperm that activate skin cells' own repair mechanisms when injected into the dermis. At Estetická klinika Hradec Králové, polynucleotide injections stimulate fibroblast proliferation, accelerate skin regeneration, improve elasticity and address specific concerns like under-eye hollows and scars. Priced from 4 500 Kč (under-eye or scars) to 6 900 Kč (face or neck), with a course of 3 sessions every 3–4 weeks.

Polynucleotides (PDRN — polydeoxyribonucleotides) are long-chain DNA fragments extracted and purified from salmon testes, where they occur naturally in high concentration. Despite the unusual origin, salmon PDRN has high structural homology with human DNA and is biocompatible, well-tolerated and non-immunogenic. When injected into the dermis, PDRN molecules are taken up by fibroblasts (the cells responsible for producing collagen and elastin) and act through adenosine A2A receptor activation — a pathway that accelerates cell proliferation, DNA repair and production of extracellular matrix proteins. The clinical result is skin regeneration from the cellular level upward: over a course of 3 injections (spaced 3–4 weeks apart), patients typically observe progressive improvement in skin texture, firmness, hydration and elasticity that feels different from both mesotherapy (which adds exogenous nutrients) and HA fillers (which add volume) — polynucleotides genuinely accelerate the skin's own regenerative capacity rather than supplementing it externally. At Estetická klinika Hradec Králové, polynucleotide treatment is available for the under-eye area (from 4 500 Kč) — a popular application because the thin periorbital skin responds well and the improvement in dark circles and hollowness is particularly visible — as well as for the face and neck (from 6 900 Kč per area) and for scar revision (from 4 500 Kč). The under-eye and scar applications take advantage of PDRN's ability to support angiogenesis (new blood vessel formation) alongside fibroblast activation, which is key to both under-eye rejuvenation and scar remodelling. Sessions take 30–45 minutes with topical anaesthetic if requested. Side effects are typically limited to mild redness and small injection papules resolving within hours. Results build cumulatively: first improvement around 2–4 weeks after the first session, with the full regenerative effect visible at 4–8 weeks after completing the course.