Type
PRP/PRF Therapy
Duration
40 min
What's included
4 deliverables in this treatment
- Physician-injected polynucleotide (PDRN) treatment into target dermis
- Under-eye, face/neck or scar-specific protocol
- 3-session course with 3–4 week spacing
- Post-treatment care instructions
Polynucleotides — sold under brand names including Rejuran — are purified DNA fragments derived from salmon sperm that activate skin cells' own repair mechanisms when injected into the dermis. At Estetická klinika Hradec Králové, polynucleotide injections stimulate fibroblast proliferation, accelerate skin regeneration, improve elasticity and address specific concerns like under-eye hollows and scars. Priced from 4 500 Kč (under-eye or scars) to 6 900 Kč (face or neck), with a course of 3 sessions every 3–4 weeks.
About this treatment
Polynucleotides (PDRN — polydeoxyribonucleotides) are long-chain DNA fragments extracted and purified from salmon testes, where they occur naturally in high concentration. Despite the unusual origin, salmon PDRN has high structural homology with human DNA and is biocompatible, well-tolerated and non-immunogenic. When injected into the dermis, PDRN molecules are taken up by fibroblasts (the cells responsible for producing collagen and elastin) and act…
The clinical result is skin regeneration from the cellular level upward: over a course of 3 injections (spaced 3–4 weeks apart), patients typically observe progressive improvement in skin texture, firmness, hydration and elasticity that feels different from both mesotherapy (which adds exogenous nutrients) and HA fillers (which add volume) — polynucleotides genuinely accelerate the skin's own regenerative capacity rather than supplementing it externally.
At Estetická klinika Hradec Králové, polynucleotide treatment is available for the under-eye area (from 4 500 Kč) — a popular application because the thin periorbital skin responds well and the improvement in dark circles and hollowness is particularly visible — as well as for the face and neck (from 6 900 Kč per area) and for scar revision (from 4 500 Kč). The under-eye and scar applications take advantage of PDRN's ability to support angiogenesis (new…
Good to know
- Active
- Polydeoxyribonucleotides (PDRN) — salmon-derived DNA fragments
- Mechanism
- Fibroblast activation, collagen/elastin production, angiogenesis
- Under-eye from
- 4 500 Kč; face/neck from 6 900 Kč
- Sessions
- 3 sessions, 3–4 weeks apart
Who is this for?
Skin regeneration, under-eye hollows and dark circles, scar revision, elasticity loss, patients wanting cellular-level skin repair.
Preparation required
No special pre-treatment preparation beyond avoiding blood thinners 24 hours before. Topical anaesthetic available on request. Avoid intense sun exposure for 1 week after.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
MUDr. Michaela Tomanová, Ph.D., MBA has been practising aesthetic and anti-aging medicine since 2003 and holds 32 professional certificates from Czech, European and international aesthetic medicine organisations. She is a certified APTOS thread-lift specialist and leads the clinic's surgical-alternative lifting portfolio. MUDr. Jana Tomanová graduated from Charles University, Faculty of Medicine in Hradec Králové…
Languages: Czech
What clients say
"Moc děkuji za aplikaci! Váš úžasný přístup. Jste skvělá! S takovou péčí jsem se jinde nesetkala! — Kristyna S."
"Ještě Vám jednou moc děkuji nejen za krásnou práci, ale ta Vaše ochota a tak empatický přístup. Jsem strašně mile překvapena a už teď vím, že nikam jinam nepůjdu. Jste opravdu profesionálka. — Vanessa P."
Treatment highlights
- Physician-injected polynucleotide (PDRN) treatment into target dermis
- Under-eye, face/neck or scar-specific protocol
+2 more items in What's included
Under-eye area from 4 500 Kč. Single area (face or neck) from 6 900 Kč. Scar treatment from 4 500 Kč. Protocol: 3 sessions every 3–4 weeks. Initial consultation 500 Kč.