Obesity & Weight Management (Endocrinologist-Led)

Specialist endocrinology-led obesity assessment and weight management programme, addressing hormonal and metabolic drivers of excess weight with tailored pharmacotherapy including anti-obesity medications.

Dr Daphne Lee's obesity and weight management programme is grounded in endocrinology — the recognition that obesity is frequently driven by hormonal dysregulation rather than simply caloric excess. As a consultant endocrinologist, Dr Lee evaluates each patient's hormonal profile to identify contributing conditions such as insulin resistance, thyroid dysfunction, PCOS, Cushing's syndrome, hypogonadism, or adrenal disorders before designing a treatment plan. The diagnostic workup typically includes comprehensive blood tests (fasting glucose, HbA1c, fasting insulin, lipid profile, thyroid function, cortisol, sex hormones), saliva cortisol testing, and imaging when clinically indicated. Based on findings, pharmacotherapy is prescribed from a range of evidence-based anti-obesity agents: appetite suppressants, insulin sensitisers (such as metformin for insulin-resistant patients), and GLP-1 receptor agonists where appropriate for patients with metabolic syndrome or type 2 diabetes overlap. Hormonal therapy is initiated when obesity stems from primary endocrine dysfunction — for example, thyroid hormone replacement for hypothyroidism-related weight gain, or testosterone therapy for hypogonadism-associated metabolic slowdown. Treatment protocols are individualised and adjusted over time based on weight trajectory, side effect profile, and evolving metabolic markers. Patients at Mount Elizabeth Novena and Gleneagles benefit from specialist-level care in a private, confidential setting. This programme is particularly suitable for patients who have struggled with weight despite diet and exercise, those with endocrine comorbidities, and patients seeking medically supervised pharmacotherapy with specialist oversight.