Type
Mesotherapy
Duration
25 min
What's included
4 deliverables in this treatment
- Skin assessment and indication review by MUDr. Moskalyková
- Sterile single-use salmon PDRN gel microinjection across agreed zones
- Post-treatment care guidance
- Course planning and spacing recommendations
Intradermal injection of salmon-derived polynucleotide (PDRN) gel at CLED — a viscoelastic, biocompatible DNA fragment preparation that hydrates and nourishes dermal fibroblasts, improving skin elasticity and firmness through a trophic rather than purely volumising mechanism. The single-use sterile gel is injected with a fine needle across any skin area including the delicate eye region, forehead, cheeks and full face. PDRN has documented effects on fibroblast proliferation and tissue repair, making it particularly useful for skin that is thin, damaged or slow to recover.
About this treatment
Polydeoxyribonucleotide (PDRN) is a purified, sterile preparation of DNA fragments derived from salmon (Oncorhynchus mykiss) gonads. The high structural similarity between salmon and human DNA allows PDRN to interact with adenosine A2A receptors on human cells, triggering anti-inflammatory and tissue-repair signalling pathways. The primary cellular effects are two-fold: first, a direct trophic stimulation of fibroblasts that increases their production of…
At CLED the PDRN preparation is formulated as a viscoelastic gel — water, polynucleotides, salt and sodium phosphate in a sterile, non-pyrogenic single-use preparation. The gel consistency allows MUDr. Moskalyková to use a microinjection technique with a very fine needle, placing small depots precisely in the dermis across the treatment zone. Because the preparation is non-cross-linked and relatively low-viscosity, it integrates into the dermis without…
Indications at CLED include thin or ageing skin with reduced elasticity, under-eye hollowing and skin quality decline, post-acne or post-inflammatory skin damage, skin recovery support after laser resurfacing or chemical peeling, and general facial rejuvenation for patients who prefer a natural, biologically derived product over synthetic fillers.
Good to know
- Active ingredient
- Salmon polynucleotides (PDRN) — viscoelastic sterile gel
- Mechanism
- Fibroblast trophic stimulation + anti-inflammatory
- Areas
- Any zone including delicate eye region
- Course
- 3 sessions, 3–4 weeks apart; maintenance every 6 months
Who is this for?
Adults with thin or ageing skin, under-eye skin quality concerns, post-laser or post-peel recovery support, or those preferring a natural biologically-derived injectable over synthetic fillers
Preparation required
Inform MUDr. Moskalyková of any fish allergy before treatment — salmon PDRN is contraindicated. Avoid aspirin and ibuprofen for 24 hours before. Do not apply retinoids or active acids to treatment areas for three days before.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
CLED is founded and led solely by MUDr. Miloslava Moskalyková, a graduate of the 1st Faculty of Medicine of Charles University (1. LF UK). She holds first-degree board certification in dermatovenerology (1997) and second-degree board certification in corrective dermatology (2000) — a two-tier specialisation that spans both medical diagnosis and aesthetic intervention. In addition to her Czech training she completed…
Languages: Czech
Treatment highlights
- Skin assessment and indication review by MUDr. Moskalyková
- Sterile single-use salmon PDRN gel microinjection across agreed zones
+2 more items in What's included
From approximately 5,000 Kč per session (market reference — contact +420 606 035 141 for current pricing). Fine-needle intradermal injection using sterile single-use salmon PDRN gel. Improvement in elasticity and skin tone builds over 2–3 sessions.