Sleep & Stress Support Panel

A 24-biomarker panel investigating the biological drivers of poor sleep, chronic stress, and burnout. Centres on morning cortisol and DHEA-S to assess adrenal function, complemented by a full thyroid panel (thyroid dysfunction is a common hidden cause of insomnia), hs-CRP for stress-related inflammation, and vitamin D and B12 — both of which directly influence sleep quality and stress resilience.

If you are wired at night but exhausted in the morning, the Sleep & Stress Support Panel investigates why. The adrenal axis is assessed through morning cortisol and DHEA-S — the ratio between these two hormones reveals whether your stress response system is in overdrive (high cortisol, depleted DHEA-S) or exhausted (both low). This distinction matters because the interventions are different. Thyroid dysfunction is one of the most overlooked causes of sleep disruption. Hyperthyroidism causes insomnia and anxiety; hypothyroidism causes fatigue despite adequate sleep time. Both are common — especially subclinical forms that do not show up on basic TSH screening — and this panel includes a complete thyroid assessment. High-sensitivity CRP measures systemic inflammation, which disrupts sleep architecture independently of other factors. Chronic low-grade inflammation activates the immune system's alerting pathways, reducing deep sleep and increasing nighttime awakenings. Vitamin D receptors exist throughout the brain including in sleep-regulating centres, and deficiency is associated with poor sleep quality, shorter sleep duration, and daytime sleepiness. A full blood count screens for anaemia and infection — both of which cause fatigue and disrupted sleep — while B12 influences melatonin production through its role in methylation pathways.