Methylation Panel

An epigenetic blood test examining how your genes influence nutrient processing, detoxification, and neurotransmitter production through methylation pathways. Methylation is a fundamental biochemical process occurring billions of times per second in every cell — it repairs DNA, produces serotonin and dopamine, deactivates histamine, processes oestrogen, and clears environmental toxins. Impaired methylation is linked to depression, fatigue, cardiovascular disease, and increased cancer risk.

Methylation is a fundamental biochemical process occurring billions of times per second in every cell — adding a methyl group to DNA, proteins, and neurotransmitters to regulate their function. It governs DNA repair, gene expression (epigenetics), neurotransmitter production and breakdown, hormone metabolism, detoxification, and immune regulation. When methylation is impaired, the downstream effects are wide-ranging. This panel measures the key markers of methylation pathway function, including cofactor levels that drive the cycle. Homocysteine is the primary clinical indicator — elevated levels signal a methylation bottleneck, typically caused by insufficient B12, folate, or B6, or by genetic variants (MTHFR, COMT, CBS) that reduce enzyme efficiency. The panel provides the data needed to identify where the bottleneck is occurring. Impaired methylation is associated with depression (reduced serotonin and dopamine production), cardiovascular disease (elevated homocysteine), histamine intolerance (impaired histamine breakdown), oestrogen dominance (impaired oestrogen detoxification), and increased cancer risk (impaired DNA repair). Many of these connections are well-established in clinical literature, though the field continues to evolve. No fasting is required. ClearLabs delivers results within 2-3 business days. The digital dashboard presents each marker against optimal ranges, and the data integrates with other ClearLabs tests — particularly the MTHFR Gene Mutation Test, B Vitamins Panel, and Homocysteine Test — to build a complete methylation profile. For anyone with known MTHFR variants or a history of depression, this panel provides actionable data for targeted supplementation.