Ozone Therapy

A 30-minute medical ozone therapy session delivering ozone-oxygen mixtures to stimulate immune function, improve oxygen metabolism, and reduce oxidative stress through controlled oxidative preconditioning.

Medical ozone therapy involves the administration of a precise ozone-oxygen mixture (O3/O2) to stimulate the body's antioxidant defence systems through a mechanism known as oxidative preconditioning. By introducing a controlled, mild oxidative stimulus, ozone therapy upregulates the body's endogenous antioxidant enzymes — superoxide dismutase (SOD), catalase, and glutathione peroxidase — resulting in a net reduction in oxidative stress rather than an increase. This hormetic effect is analogous to exercise: a short-term stress that triggers adaptive responses leading to long-term resilience. The physiological effects of medical ozone include enhanced oxygen delivery to tissues (ozone improves the flexibility of red blood cells and their ability to release oxygen via the Bohr effect), immune modulation (stimulating cytokine production at low concentrations while suppressing excessive inflammatory responses), and antimicrobial activity against bacteria, viruses, and fungi. These properties make ozone therapy applicable across a wide range of conditions, from chronic infections to inflammatory disorders to circulatory problems. At Circle Health, ozone therapy is administered by trained medical staff using calibrated ozone generators that produce precise concentrations. The specific administration method is selected based on the clinical indication and may include major autohemotherapy (blood is drawn, mixed with ozone, and reinfused), rectal insufflation, or direct injection into joints or trigger points. Ozone therapy is frequently combined with IV vitamin infusions at Circle Health — the enhanced oxygen metabolism from ozone can improve the cellular uptake and utilisation of nutrients delivered intravenously. At €39 per session, it is one of the clinic's most affordable therapeutic modalities and is often integrated into broader treatment plans for patients addressing chronic fatigue, immune dysfunction, or inflammatory conditions.