IV Therapy — NAD+ Infusion

A 2-hour intravenous NAD+ infusion delivering nicotinamide adenine dinucleotide directly into the bloodstream to support cellular energy production, DNA repair, and anti-ageing pathways.

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell, essential for hundreds of metabolic reactions including mitochondrial energy production, DNA repair, and the activation of sirtuins — a family of proteins that regulate cellular ageing and stress resistance. NAD+ levels decline significantly with age, falling by roughly 50% between ages 40 and 60, and this decline is increasingly recognised as a driver of age-related metabolic dysfunction, cognitive decline, and reduced cellular resilience. Intravenous NAD+ bypasses the digestive system entirely, delivering the coenzyme directly into the bloodstream at concentrations that oral precursors (NMN, NR) cannot match. The 2-hour infusion time reflects the need for slow administration — NAD+ delivered too quickly can cause uncomfortable flushing, chest tightness, and nausea. Circle Health's medical team calibrates the drip rate to each patient's tolerance, typically starting slower and adjusting upward as the body acclimates. The physiological effects of NAD+ repletion are wide-ranging: enhanced mitochondrial function (more efficient ATP production), upregulated DNA repair via PARP enzymes, sirtuin activation (which influences gene expression patterns associated with longevity), and improved neurotransmitter synthesis. Many patients report increased mental clarity, sustained energy without stimulant-like peaks and crashes, and improved exercise recovery within the first few sessions. At €249, the NAD+ infusion is Circle Health's premium IV offering and is typically recommended as a course of 4-6 sessions for initial loading, followed by monthly maintenance. It is often combined with red light therapy or IHHT altitude training as part of a comprehensive longevity protocol tailored to each patient's biomarker data.