NAD+ Infusion Therapy

Intravenous NAD+ (nicotinamide adenine dinucleotide) infusions to support cellular energy production, DNA repair, and sirtuin activation — key pathways in longevity biology. NAD+ declines with age; IV supplementation aims to restore intracellular NAD+ levels to support mitochondrial function, cognitive clarity, and metabolic health. Protocols typically involve one to three sessions for acute repletion followed by maintenance infusions.

NAD+ infusion therapy at Central Coast Longevity in Gosford delivers nicotinamide adenine dinucleotide — a coenzyme central to cellular metabolism — intravenously to replenish intracellular NAD+ stores that decline significantly with age. Research in longevity biology has identified NAD+ as a critical regulator of several hallmarks of ageing: it is an essential substrate for sirtuins (SIRT1–7), a family of NAD+-dependent deacetylases that regulate gene expression, mitochondrial biogenesis, and stress resistance; it is required by PARP enzymes (poly-ADP-ribose polymerases) for DNA strand break repair, a process that becomes increasingly important as cumulative oxidative DNA damage accumulates with age; and it is a direct substrate for the mitochondrial electron transport chain, underpinning cellular ATP (energy) synthesis. Studies in animal models have demonstrated that restoring NAD+ levels in aged animals can reverse aspects of metabolic decline, improve muscle function, and extend median lifespan; human trials, while earlier-stage, support improvements in fatigue, cognitive function, and metabolic markers following NAD+ repletion. At the Gosford clinic on the NSW Central Coast, NAD+ infusions are delivered as slow intravenous infusions over two to four hours — a pacing necessary to minimise the common side effects of nausea, flushing, and chest tightness that occur with too-rapid infusion rates. Clients from across the Central Coast pursuing longevity, anti-ageing, and metabolic optimisation goals access NAD+ therapy as a foundational protocol, often combined with hormone testing and IV nutrient infusions as part of a structured programme. A standard repletion course consists of one to three consecutive-day infusions, followed by monthly maintenance sessions.