Ozone Therapy

Ozone autohemotherapy session where a small volume of blood is drawn, enriched with medical-grade ozone (O₃), and reinfused intravenously to support immune modulation and circulatory health.

Ozone autohemotherapy at Burnout-Praxis Berlin follows the major autohemotherapy (MAH) protocol: approximately 100-200ml of venous blood is drawn into a sterile, closed-system collection bag, mixed with a precise concentration of medical-grade ozone-oxygen gas, and then reinfused into the patient via the same venous access. The entire process takes around 30 minutes and is performed under clinical supervision. The therapeutic rationale centres on ozone's oxidative preconditioning effect. When ozone contacts blood ex vivo, it reacts with unsaturated fatty acids in plasma to produce lipid ozonation products (LOPs) — primarily hydrogen peroxide and 4-hydroxynonenal. These signalling molecules, when reinfused at controlled concentrations, upregulate antioxidant enzyme systems (superoxide dismutase, glutathione peroxidase, catalase) and stimulate the Nrf2 pathway, which governs the body's endogenous antioxidant defence. This is a hormetic response: a small, controlled oxidative challenge triggers a disproportionately large protective adaptation. Clinically, ozone therapy is used across European integrative medicine for chronic fatigue, immune dysregulation, circulatory insufficiency, and as an adjunct in chronic infection management. The German medical system has a long tradition of ozone therapy — it has been practised in Germany since the 1950s and is offered by thousands of physicians, though it remains outside statutory health insurance coverage. At €85 per session, Burnout-Praxis Berlin's pricing is in line with the typical range for major autohemotherapy in German integrative practices (€70-120). The 30-minute session length allows it to be combined with other modalities offered at the clinic, such as IV laser therapy or IHHT, for patients pursuing comprehensive protocols.