Exosomes AutologIX (1 area)

Exosome facial rejuvenation using the AutologIX protocol — a regenerative treatment that delivers concentrated exosomes (cell-derived signalling vesicles) into the skin to accelerate tissue repair, stimulate fibroblast activity, and enhance collagen and elastin production at a cellular level.

The Exosomes AutologIX treatment at Bona Dea represents the newest generation of regenerative aesthetic medicine. Exosomes are nano-sized extracellular vesicles (30-150nm) naturally released by cells as part of intercellular communication. They carry a cargo of growth factors, cytokines, mRNA, and microRNA that instruct recipient cells to activate specific biological processes — including tissue repair, collagen synthesis, anti-inflammatory responses, and cellular renewal. The AutologIX protocol uses a concentrated preparation of exosomes to deliver this regenerative signalling directly to the skin. The treatment area — typically the face, neck, or décolletage — is first prepared with microneedling or a fractional device to create thousands of micro-channels in the skin. The exosome solution is then applied topically and massaged into these channels, allowing the nano-sized vesicles to penetrate beyond the stratum corneum and reach the dermal fibroblasts, keratinocytes, and endothelial cells where they exert their regenerative effects. This combination approach (micro-channel creation + exosome delivery) ensures significantly deeper penetration than topical application alone. Once the exosomes reach their target cells, they fuse with the cell membrane and release their bioactive cargo intracellularly. The growth factors and signalling molecules activate dormant fibroblasts, upregulate collagen type I and III synthesis, promote angiogenesis (new blood vessel formation for improved skin nutrition), and modulate the inflammatory response to favour regeneration over scarring. The net clinical effect is improved skin quality — better hydration, firmer texture, reduced fine lines, enhanced radiance, and a more even complexion — that develops progressively over 4 to 8 weeks. Bona Dea recommends a course of 3 sessions spaced 3 to 4 weeks apart for optimal results, with maintenance sessions every 6 to 12 months. Exosome therapy is suitable for patients of all ages and skin types, and can be combined with other treatments (Botox, fillers, laser) in a comprehensive rejuvenation programme. Downtime is minimal — redness and mild swelling from the microneedling component resolve within 24-48 hours.