Predictive Genomics (SNP Analysis)

5P Medicine's predictive genomics service analyses single nucleotide polymorphisms (SNPs) to identify inherited predispositions to civilisation diseases — cardiovascular risk, metabolic disorders, certain cancers and neurodegenerative conditions — before any symptoms appear. DNA is processed in partnership with Laboratoires REUNIS in Luxembourg, one of Europe's leading specialist genomics laboratories. MUDr. Hora, who performed the first genomic examination in the Plzeň region back in 2009, interprets results in a detailed personalised report and translates genetic risk factors into actionable lifestyle, diet and supplementation recommendations. The key insight: predisposition is not destiny — environmental and lifestyle factors can modulate gene expression significantly.

Predictive genomics at 5P Medicine uses high-resolution SNP (single nucleotide polymorphism) profiling to map an individual's inherited susceptibility to a wide range of chronic conditions. Unlike a family history conversation, SNP analysis quantifies risk at the molecular level, identifying specific gene variants associated with cardiovascular disease, type 2 diabetes, obesity, selected cancers, thyroid dysfunction and neurodegenerative disorders. The DNA sample (typically a buccal swab or blood draw) is sent to Laboratoires REUNIS in Luxembourg — 5P Medicine's partner since 2011 — where it undergoes comprehensive array-based genotyping. Results are returned to the clinic and interpreted by MUDr. Petr Hora MBA, who has been working in genomics since 2003 and performed the first genomic exam in the Plzeň region in 2009. The process unfolds in three stages. First, a pre-test consultation clarifies which risk areas are most relevant for the patient's age, symptoms and family background. The sample is then collected and dispatched; analysis typically takes two to four weeks. Finally, a results consultation covers every flagged variant in plain language, cross-referencing current evidence on penetrance and modifiability. The written report includes a prioritised list of preventive measures: dietary changes, specific micronutrient supplementation, physical activity targets and, where appropriate, enhanced monitoring schedules. The fundamental principle is that a genetic predisposition is a probability, not a sentence. External factors — diet, sleep, stress management, toxin avoidance, microbiome health — can shift phenotypic expression substantially, even for high-penetrance variants. This makes genomic testing most valuable when combined with microbiome analysis, hormone profiling and epigenetic age assessment, as offered through 5P Medicine's multi-omics AI programmes. Ideal candidates include adults with a family history of early chronic disease, those planning pregnancy who want a baseline genetic profile for their child, individuals with unexplained metabolic or hormonal issues, and prevention-oriented biohackers seeking the deepest possible understanding of their biology. Contraindications are few; the main consideration is psychological readiness to receive and act on risk information, which Dr. Hora addresses during the pre-test counselling session.