Type
Biological Age Panel
Duration
30 min
Sample
Blood (venous draw)
What's included
5 deliverables in this treatment
- Blood draw at the clinic for methylation profiling
- MethylAge analysis measuring 5mC and 5hmC methylation markers
- Biological age estimate with comparison to age-matched reference population
- Assessment of epigenetic age acceleration vs chronological age
- Personalised recommendations to improve methylation health (diet, supplements, lifestyle)
The MethylAge epigenetic test at 5P Medicine measures two key DNA methylation markers — 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) — to determine how fast a patient's cells are actually ageing compared to their chronological age. High 5hmC is associated with active, 'younger' DNA; a low ratio suggests accelerated epigenetic ageing. Results translate directly into a biological age assessment, with personalised lifestyle recommendations designed to slow or reverse measurable epigenetic ageing. This test is particularly valuable for patients aged 35+ who want objective data on their cellular ageing trajectory before symptoms appear.
About this treatment
Epigenetics describes how external factors — diet, stress, sleep, environmental toxins, exercise — alter which genes are expressed without changing the underlying DNA sequence. DNA methylation is one of the best-studied epigenetic mechanisms: the addition or removal of methyl groups to cytosine bases acts as an on/off switch for gene expression, and the overall pattern shifts in characteristic ways as we age.
The MethylAge test used at 5P Medicine quantifies two specific methylation states in a blood sample:
5-methylcytosine (5mC) reflects baseline DNA methylation levels and correlates with gene silencing and genomic stability. Global hypomethylation — a reduction in 5mC across the genome — is a well-documented hallmark of cellular ageing and is associated with increased cancer risk and loss of transcriptional regulation.
Good to know
- Markers measured
- 5-methylcytosine (5mC) + 5-hydroxymethylcytosine (5hmC)
- Output
- Biological age estimate + epigenetic age acceleration score
- Sample type
- Blood (venous draw)
- Clinical use
- Longevity baseline; track response to interventions
Who is this for?
Adults 35+ seeking objective cellular ageing data; biohackers; those with family history of early ageing-related diseases
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
The clinic is led by MUDr. Petr Hora MBA (born 1969, Plzeň), a Charles University Medical Faculty graduate with a background in anaesthesiology, intensive care and air rescue. Dr. Hora pivoted to genomics and preventive medicine in 2003, performed the first genomic exam in Plzeň in 2009, and visited the Mayo Clinic in 2018. He is a member of A4M, ACLM, ESNM and IFM — four of the leading international bodies for…
Languages: Czech
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Treatment highlights
- Blood draw at the clinic for methylation profiling
- MethylAge analysis measuring 5mC and 5hmC methylation markers
+3 more items in What's included
Price on application — bundled within AI therapeutic programmes. Standalone MethylAge test available; call +420 602 791 007 for a quote. Blood draw at clinic required.